I don""t believe in myself no more." He finally admitted that he was fearful of losing everything he had achieved: "The truth is, I don""t wanna lose what I got.As a footnote, it was refilmed 34 years later (a record for an interval of time between a sequel and its original) in the mid-70s as the satiricalBlack Bird (1975)with George Segal as son Sam Spade, Jr.Over the next four years, George manages the company while his brother attends college in his place.When Harry graduates from college in 1932, he is to come back to Bedford Falls and run he family business.It was a "gene therapy that allows the brain to create its own cells in order to repair itself" - a process called neurogenesis.But he appears to have lost his immortal soul with a wild look in his eyes: "Why he""s mad! Look at his eyes.